2′-C-Methyluridine

Category:

ArtikelNr.

MBCB001001

CAS Nr.

31448-54-1

Name

2′-C-Methyluridine

Description

2′-C-Methyluridine is an inorganic compound that can be used as a building block for nucleoside synthesis. It is a diastereomer of uridine and has been shown to have antiviral properties in transfection experiments. 2′-C-Methyluridine competitively inhibits the phosphorylation of uridine by viral enzymes, which prevents viral replication. This modification also inhibits viral protein synthesis. It is made synthetically from the reaction between an organic base and a hydroxyl group, with subsequent dephosphorylation. 2′-C-Methyluridine has been shown to inhibit the virus that causes rabies, herpes simplex virus type 1, and influenza A virus.

Specification规格 (g)

100

Chemical Formula:

C10H14N2O6

Molecular Weight:

258.23 g/mol

Appearance:

White to off-white powder

Purity (HPLC):

min 98%

Identity (1H NMR) (DMSO):

Conforms to structure

Residual protic solvents (including water):

max 0.5%

Benzoic acid:

None detected

 

Hazards identification

  • Health Hazards

serious irritation (Category 2) serious irritation (Category 2) acute toxicity (Category 4) (single exposure), STOT SE3

  • Enviromental Hazards

not classified

  • Physical Hazards

not classified

 

GHS Labeling

  • Regulatory List

EC1272/08 Regulation (EC) 1272/2008 (GHS/CLP)

  • Symbol

GHS07 exclamation mark

  • Pictogram
  • Signal Word

Warning Warning

  • Hazard Statement

H302 Harmful if swallowed.

H315 Causes skin irritation.

H319 Causes serious eye irritation.

H335 May cause respiratory irritation.

  • Precautionary Statement

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P264 Wash thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P304 IF INHALED:

P340 Remove casualty to fresh air and keep at rest inaposition comfortable for breathing. P305 IF IN EYES:

P351 Rinse cautiously with water for several minutes.

P338 Remove contact lenses, if present and easy to do.Continue rinsing.

P330 Rinse mouth.

P362 Take off contaminated clothing and wash before reuse.

P364 And wash it before reuse.

 

First aid measures

  • First Aid: Eye

Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist.

  • First Aid: Skin

Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.

  • First Aid: Ingestion

Wash out mouth with water provided person is conscious. Call a physician.

  • First Aid: Inhalation

Remove casualty to fresh air and keep warm and at rest. If breathing is irregular or stopped, administer artificial respiration. Call a physician.

  • Hints for Physician: Treatment

Treat symptomatically.

 

Accidental release measures

  • Personal Precautions

Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation.

  • Environmental Precautions

Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains. Ensure all waste water is collected and treated via a waste water treatment plant.

  • Methods for Cleaning or Taking Up

not available

  • Further Accidental Release Measures

Collect in closed and suitable containers for disposal. Clear contaminated areas thoroughly. Ventilate affected area.

 

Handling advice

Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling.

 

Storage

  • Storage temperature

store at 10°C – 25°C

  • Storage Requirements

Keep away from incompatible substances. Store in a cool, dry, well-ventilated area away from incompatible substances.

 

Personal Protective Equipment

  • Respiratory Protection

Wear NIOSH/MSHA or European Standard EN 149 approved respirator.

  • Hand Protection

Wear compatible chemical-resistant gloves to prevent skin exposure.

  • Eye Protection

Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA.

  • Body Protection

Wear compatible chemical-resistant gloves and clothing to prevent skin exposure.

  • Advice on Safe Handling

Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.

 

Physical and chemical properties

  • Form

powder

  • Phase Transition Solid/Liquid

101.00 °C

  • Molar Mass

258.23 g/mol

Stability and reactivity

  • Conditions to Avoid

incompatible materials

  • Substances to Avoid

strong oxidizers

  • Decomposition Products

nitrogen oxides (NOx), carbon dioxide (CO2), carbon monoxide

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