2,3,4,6-tetra-O-benzyl-D-glucopyranose

Category:

ArtikelNr.

MBCA002022

CAS Nr.

4132-28-9

Name

2,3,4,6-tetra-O-benzyl-D-glucopyranose

Description

2,3,4,6-Tetra-O-benzyl-D-glucopyranose is a selectively protected intermediate, where the anomeric 1-O-hydroxyl group is free. This hemiacetal has been used successfully as an intermediate for glucosylation couplings, where it was converted into 2,3,4,6-tetra-O-benzyl-D-glucopyranose trichloroacetimidate using trichloroacetonitrile in the presence of a base such as potassium carbonate and DBU. Importantly, this imidate donor with no neighbouring participating groups is commonly used for the selective formation of α-glucosides. 2,3,4,6-tetra-O-benzyl-D-glucopyranose can also be oxidized to the lactone, or reduced to give the open chain form. Additionally, 2,3,4,6-tetra-O-benzyl-D-glucopyranose can be used for the preparation of glucono-1,5-lactone hydrazine, which was used, in-turn, to form a glucosylidene-spirocyclopropane.

Classification (分类)

Glucose derivatives

Specification规格 (g)

100

Chemical Formula:

C34H36O6

Molecular Weight:

540.65 g/mol

Classification of the substance or mixturet

  • Physical Hazards

not classified

  • Health Hazards

Skin irritation (Category 2), H315

Eye irritation (Category 2), H319

acute toxicity (Category 4)

Specific target organ toxicity, single exposure (Category 3), H335

  • Enviromental Hazards

not classified

 

Label elements

  • Regulatory List

EC1272/08 Regulation (EC) 1272/2008 (GHS/CLP)

  • Symbol

GHS07 exclamation mark

  • Pictogram
  • Signal Word

Warning Warning

  • Hazard Statement

H302 Harmful if swallowed.

H315 Causes skin irritation.

H319 Causes serious eye irritation.

H335 May cause respiratory irritation.

  • Precautionary Statement

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352 IF ON SKIN: Wash with plenty of soap and water.

P304+P340 IF INHALED: Remove casualty to fresh air and keepat rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Remove contact lenses, if possible.

P501 Dispose of contents / container in accordance with local / regional / national / international regulations.

 

Description of first aid measures

  • First Aid: Eye

Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist.

  • First Aid: Skin

Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.

  • First Aid: Ingestion

Wash out mouth with water provided person is conscious. Call a physician.

 

Accidental release measures

  • Personal Precautions, potective equipment and emergency procedures

Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation.

  • Environmental Precautions

Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains. Ensure all waste water is collected and treated via a waste water treatment plant.

  • Methods and material for containment and cleaning up

not available

  • Further Accidental Release Measures

Collect in closed and suitable containers for disposal. Clear contaminated areas thoroughly. Ventilate affected area.

 

Handling advice

Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling.

 

Conditions for safe storage, including any incompatibilities

  • Storage temperature

store at <-15°C

  • Storage condition

close container well, protect from light

  • Storage Requirements

Warm to Room Temperature before use. Keep away from incompatible substances. Store in a cool, dry, well-ventilated area away from incompatible substances.

 

Personal Protective Equipment

  • Respiratory Protection

Wear NIOSH/MSHA or European Standard EN 149 approved respirator.

  • Hand Protection

Wear compatible chemical-resistant gloves to prevent skin exposure.

  • Eye Protection

Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA.

  • Body Protection

Wear compatible chemical-resistant gloves and clothing to prevent skin exposure.

  • Advice on Safe Handling

Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.

 

Information on basic Physical and chemical color properties

  • Color

white

  • Form

powder

  • Phase Transition Solid/Liquid

150 °C

 

Stability and reactivity

  • Reactivity

No Data Available

  • Chemical stability

No Data Available

  • Possibility of hazardous reaction

No Data Available

  • Conditions to Avoid (SDS)

heat, light

  • Incompatible materials

strong acids, strong oxidizers

  • Hazardous decomposition products

carbon dioxide (CO2), carbon monoxide

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