4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Category:

ArtikelNr.

MBCC001029

CAS Nr.

327-78-6

Name

4-Chloro-3-(trifluoromethyl)phenyl isocyanate

Description

4-Chloro-3-(trifluoromethyl)phenyl isocyanate (4CTFPI) is a phenoxy that has significant antiproliferative activity and can be used to treat cancer. It can inhibit the growth of tumor cells by suppressing the production of growth factors and binding to the receptor for these factors, which leads to inhibition of cell division. 4CTFPI also inhibits tumor growth through its ability to induce apoptosis in cancer cells. 4CTFPI has been shown to have antitumor effects on sarcoma cells in vitro and in vivo with a low toxicity profile. This compound is not active against bacterial infections or fungi, but it does not show any carcinogenic effects.

Specification规格 (g)

100

Chemical Formula:

C8H3ClF3NO

Molecular Weight:

221.56 g/mol

 

Classification of the substance or mixturet

  • Physical Hazards

not classified

  • Health Hazards

Acute toxicity inhalation (Category 2), H330 Skin irritation (Category 2), H315

Skin sensitiser (Category 1), H317

Eye damage (Category 1), H318

Acute toxicity oral (Category 4), H302

  • Enviromental Hazards

Acute aquatic toxicity (Category 1), H400

Chronic aquatic toxicity (Category 1), H410

 

Label elements

  • Regulatory List

EC1272/08 Regulation (EC) 1272/2008 (GHS/CLP)

  • Symbol

GHS05 corrosion

  • Pictogram

GHS06 skull and crossbones

  • Pictogram

GHS07 exclamation mark

  • Pictogram

GHS09 environmental hazards

  • Pictogram
  • Signal Word

Danger Danger

  • Hazard Statement

H302 Harmful if swallowed.

H315 Causes skin irritation.

H317 May cause an allergic skin reaction.

H318 Causes serious eye damage.

H330 Fatal if inhaled.

H400 Very toxic to aquatic life.

H410 Very toxic to aquatic life with long lasting effects.

  • Precautionary Statement

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowedout of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352 IF ON SKIN: Wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,

if present and easy to do. Remove contact lenses, if possible. P362 Take off contaminated clothing and wash before reuse.

P501 Dispose of contents / container in accordance with local / regional / national / international regulations.

 

Description of first aid measures

  • First Aid: Eye

Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist.

  • First Aid: Skin

Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.

  • First Aid: Ingestion

Wash out mouth with water provided person is conscious. Call a physician.

 

Accidental release measures

  • Personal Precautions, potective equipment and emergency procedures

Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation.

  • Environmental Precautions

Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains. Ensure all waste water is collected and treated via a waste water treatment plant.

  • Methods and material for containment and cleaning up

not available

  • Further Accidental Release Measures

Collect in closed and suitable containers for disposal. Clear contaminated areas thoroughly. Ventilate affected area.

 

Handling advice
Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling.

 

Conditions for safe storage, including any incompatibilities

  • Storage temperature

store at 2°C – 8°C

  • Storage condition

keep dry, keep under inert gas: Nitrogen

  • Storage Requirements

Keep container tightly closed when not in use, since hygroscopic. Keep away from incompatible substances.

 

Personal Protective Equipment

  • Respiratory Protection

Wear NIOSH/MSHA or European Standard EN 149 approved respirator.

  • Hand Protection

Wear compatible chemical-resistant gloves to prevent skin exposure.

  • Eye Protection

Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA.

  • Body Protection

Wear compatible chemical-resistant gloves and clothing to prevent skin exposure.

  • Advice on Safe Handling

Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.

 

Information on basic Physical and chemical color properties

  • Form

powder

  • Phase Transition Solid/Liquid

36 °C

 

Stability and reactivity

  • Reactivity

No Data Available

  • Chemical stability

No Data Available

  • Possibility of hazardous reaction

No Data Available

  • Conditions to Avoid (SDS)

moisture, air

  • Incompatible materials

strong oxidizers

  • Hazardous decomposition products

nitrogen oxides (NOx), carbon dioxide (CO2), hydrogen chloride (HCl), hydrogen fluoride, carbon monoxide

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