Avibactam acid

Category:

ArtikelNr.

MBCC001021

CAS Nr.

1192500-31-4

Name

Avibactam acid

Description

Avibactam is a non-beta-lactam beta-lactamase inhibitor that prevents the formation of beta-lactamases, and thus extends the spectrum of beta-lactams. It is active against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococcus faecium. Avibactam has been shown to be effective in inhibiting polymerase chain reaction (PCR) amplification of bacterial targets, such as 16S ribosomal RNA, DNA gyrase and topoisomerase IV. This drug also inhibits the synthesis of antimicrobial peptides by human macrophages and can be used as an antimicrobial agent for infectious diseases with clinical relevance. The stability of avibactam at high pH makes it suitable for use in sodium salts solutions. Avibactam binds to penicillin-binding proteins (PBPs) on the

 

Specification规格 (g)

0.25

Chemical Formula:

C7H11N3O6S

 

Molecular Weight:

265.24 g/mol

 

Classification of the substance or mixturet

  • Physical Hazards

not classified

  • Health Hazards

not classified

  • Enviromental Hazards

not classified

 

Label elements

  • Regulatory List

EC1272/08 Regulation (EC) 1272/2008 (GHS/CLP)

  • Symbol

not regulated

  • Pictogram

not regulated

  • Signal Word

not available

  • Precautionary Statement

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P262 Do not get in eyes, on skin, or on clothing.

 

Description of first aid measures

  • First Aid: Eye

Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist.

  • First Aid: Skin

Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.

  • First Aid: Ingestion

Wash out mouth with water provided person is conscious. Call a physician.

 

Accidental release measures

  • Personal Precautions, potective equipment and emergency procedures

Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation.

  • Environmental Precautions

Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains. Ensure all waste water is collected and treated via a waste water treatment plant.

  • Methods and material for containment and cleaning up

not available

  • Further Accidental Release Measures

Collect in closed and suitable containers for disposal. Clear contaminated areas thoroughly. Ventilate affected area.

 

Handling advice
Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling.

 

Conditions for safe storage, including any incompatibilities

  • Storage temperature

store at <-15°C

  • Storage condition

close container well

  • Storage Requirements

Warm to Room Temperature before use. Store in a cool, dry, well-ventilated area away from incompatible substances.

 

Personal Protective Equipment

  • Respiratory Protection

Wear NIOSH/MSHA or European Standard EN 149 approved respirator.

  • Hand Protection

Wear compatible chemical-resistant gloves to prevent skin exposure.

  • Eye Protection

Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA.

  • Body Protection

Wear compatible chemical-resistant gloves and clothing to prevent skin exposure.

  • Advice on Safe Handling

Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.

 

Information on basic Physical and chemical color properties

  • Form

powder

 

Stability and reactivity

  • Reactivity

No Data Available

  • Chemical stability

No Data Available

  • Possibility of hazardous reaction

No Data Available

  • Conditions to Avoid (SDS)

incompatible materials, air

  • Incompatible materials

strong oxidizers

  • Hazardous decomposition products

nitrogen oxides (NOx), carbon dioxide (CO2), sulphur oxides, carbon monoxide

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