(S)- (-)-3-Aminoquinuclidine 2HCl







(S)- (-)-3-Aminoquinuclidine 2HCl


(S)-(-)-3-Aminoquinuclidine 2HCl is a cholinergic agonist that has been shown to be effective in inducing the release of acetylcholine from brain synaptosomes. This drug binds to the nicotinic acetylcholine receptor (nAChR) and inhibits the action of the enzyme acetylcholinesterase, thereby increasing the concentration of acetylcholine in the synaptic cleft. The drug is also able to cross the blood-brain barrier and bind to receptors on neurons. It has been shown that this drug can be used as an imaging agent for molecular magnetic resonance tomography (MRT), with high sensitivity and specificity.

Classification (分类)


Specification规格 (g)


Chemical Formula:



Molecular Weight:

199.12 g/mol


Classification of the substance or mixturet

  • Physical Hazards

not classified

  • Health Hazards

Skin irritation (Category 2), H315

Eye irritation (Category 2), H319

Specific target organ toxicity, single exposure (Category 3), H335

  • Enviromental Hazards

not classified


Label elements

  • Regulatory List

EC1272/08 Regulation (EC) 1272/2008 (GHS/CLP)

  • Symbol

GHS07 exclamation mark

  • Pictogram
  • Signal Word

Warning Warning

  • Hazard Statement

H315 Causes skin irritation.

H319 Causes serious eye irritation. H335 May cause respiratory irritation.

  • Precautionary Statement

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352 P304+P340

IF ON SKIN: Wash with plenty of soap and water.

IF INHALED: Remove casualty to fresh air and keepat rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Remove contact lenses, if possible.

P362+P364 Take off contaminated clothing and wash it before reuse.


Description of first aid measures

  • First Aid: Eye

Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist.

  • First Aid: Skin

Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.

  • First Aid: Ingestion

Wash out mouth with water provided person is conscious. Call a physician.


Accidental release measures

  • Personal Precautions, potective equipment and emergency procedures

Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation.

  • Environmental Precautions

Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains. Ensure all waste water is collected and treated via a waste water treatment plant.

  • Methods and material for containment and cleaning up

not available

  • Further Accidental Release Measures

Collect in closed and suitable containers for disposal. Clear contaminated areas thoroughly. Ventilate affected area.


Handling advice

Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling.


Conditions for safe storage, including any incompatibilities

  • Storage temperature

store at 10°C – 25°C

  • Storage Requirements

Keep away from incompatible substances. Store in a cool, dry, well-ventilated area away from incompatible substances.


Personal Protective Equipment

  • Respiratory Protection

Wear NIOSH/MSHA or European Standard EN 149 approved respirator.

  • Hand Protection

Wear compatible chemical-resistant gloves to prevent skin exposure.

  • Eye Protection

Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA.

  • Body Protection

Wear compatible chemical-resistant gloves and clothing to prevent skin exposure.

  • Advice on Safe Handling

Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.


Information on basic Physical and chemical color properties

  • Color


  • Form


  • Phase Transition Solid/Liquid

> 260,00 °C


Stability and reactivity

  • Reactivity

No Data Available

  • Chemical stability

No Data Available

  • Possibility of hazardous reaction

No Data Available

  • Conditions to Avoid (SDS)

incompatible materials

  • Incompatible materials

strong oxidizers

  • Hazardous decomposition products

nitrogen oxides (NOx), carbon dioxide (CO2), hydrogen chloride (HCl), carbon monoxide


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