Tetrahydro-4H-pyran-4-one is a hydrochloric acid salt of tetrahydropyran-4-one. It is a colorless oil with a boiling point of 8°C and a melting point of -78°C. Tetrahydro-4H-pyran-4-one can be used to synthesize quinoline derivatives, which are important in the synthesis of many pharmaceuticals and agrochemicals. Tetrahydro-4H-pyran-4-one can also be used to synthesize other compounds, such as carbonyl groups or hydrogen bonds. The reaction solution will be stable due to the formation of stable complexes with hydrogen bonds. NMR spectra show that tetrahydro pyran 4 one has an asymmetric synthesis and isolated yield.

Classification (分类)


Specification规格 (g)


Chemical Formula:



Molecular Weight:

100.12 g/mol


Classification of the substance or mixturet

  • Physical Hazards

Flammable liquid (Category 3), H226

  • Health Hazards

not classified

  • Enviromental Hazards

not classified


Label elements

  • Regulatory List

EC1272/08 Regulation (EC) 1272/2008 (GHS/CLP)

  • Symbol

GHS02 flame

  • Pictogram
  • Signal Word

Warning Warning

  • Hazard Statement

H226 Flammable liquid and vapour.

  • Precautionary Statement

P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.

P280 Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353IF ON SKIN (or hair): Remove/Take off immediatelyall contaminated clothing. Rinse skin with water/shower. P370+P378 In case of fire: Use for extinction.

P501 Dispose of contents / container in accordance with local / regional / national / international regulations.


Description of first aid measures

  • First Aid: Eye

Immediately flush eyes with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Consult an ophthalmologist.

  • First Aid: Skin

Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.

  • First Aid: Ingestion

Wash out mouth with water provided person is conscious. Call a physician.


Accidental release measures

  • Personal Precautions, potective equipment and emergency procedures

Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation.

  • Environmental Precautions

Do not allow to enter into soil/subsoil. Do not allow to enter into surface water or drains. Ensure all waste water is collected and treated via a waste water treatment plant.

  • Methods and material for containment and cleaning up

not available

  • Further Accidental Release Measures

Collect in closed and suitable containers for disposal. Clear contaminated areas thoroughly. Ventilate affected area.


Handling advice

Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Avoid prolonged or repeated exposure. Remove contaminated clothing and wash before reuse. Wash thoroughly after handling.


Conditions for safe storage, including any incompatibilities

  • Storage temperature

store at 10°C – 25°C

  • Storage condition

keep under inert gas: Nitrogen

  • Storage Requirements

Keep container tightly closed in an upright position to prevent leakage. Keep away from incompatible substances. Keep away from heat, sparks and flame. Store in a cool, dry, well-ventilated area away from incompatible substances.


Personal Protective Equipment

  • Respiratory Protection

Wear NIOSH/MSHA or European Standard EN 149 approved respirator.

  • Hand Protection

Wear compatible chemical-resistant gloves to prevent skin exposure.

  • Eye Protection

Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA.

  • Body Protection

Wear compatible chemical-resistant gloves and clothing to prevent skin exposure.

  • Advice on Safe Handling

Wash contaminated clothing before reuse. Wear appropriate protective clothing to prevent exposure.


Information on basic Physical and chemical color properties

  • Color


  • Form

clear liquid

  • Density

1,084 g/cm3

  • Flash Point

55 °C

Stability and reactivity

  • Reactivity

No Data Available

  • Chemical stability

No Data Available

  • Possibility of hazardous reaction

No Data Available

  • Conditions to Avoid (SDS)

incompatible materials, air

  • Incompatible materials

strong bases, strong oxidizers

  • Hazardous decomposition products

carbon dioxide (CO2), carbon monoxide


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